http://tdudspace.texicon.in:8080/jspui/handle/123456789/26 Tue, 14 Apr 2026 19:30:32 GMT 2026-04-14T19:30:32Z http://tdudspace.texicon.in:8080/jspui/handle/123456789/724 Title: Effect of processing methods on fatty acid composition and flavour profile of clarified butter (ghee) obtained from Deoni and Holstein Friesian cow breeds Authors: Kataria, Deepshikha; Singh, Gurmeet Abstract: The study investigated the impact of three processes—curd-butter (CD), cream-butter (CM) and fermented cream-butter (FC) on fatty acid composition and volatile profiles of clarified butter (ghee) obtained from two cow breeds, Deoni (DN) and Holstein Friesian (HF). Gas chromatography-mass spectrometry (GC–MS) identified 26 fatty acids in ghee. There was no difference in fatty acid composition due to processing. Significant differences were observed by breed, with HF ghee exhibiting higher polyunsaturated fatty acids and α-linolenic acid than DN ghee. Headspace GC–MS detected 57 volatile compounds. Ghee made with CD and FC processes exhibited higher levels of acids, alcohols, heat degradation products, lactones, ketones, 5-hydroxymethylfurfural and maltol in both breeds. These findings suggest that processing methods alter ghee’s volatile compounds without significantly affecting fatty acid composition. Since ghee is a complex lipid, untargeted lipidomics and metabolomics studies can provide further insight into the effects of processing on ghee. This study can guide dairy processors in selecting milk sources and ghee processes to enhance flavour in ghee while maintaining fatty acid composition across cow breeds for product improvement. Tue, 01 Apr 2025 00:00:00 GMT http://tdudspace.texicon.in:8080/jspui/handle/123456789/724 2025-04-01T00:00:00Z http://tdudspace.texicon.in:8080/jspui/handle/123456789/719 Title: Glycated hemoglobin levels and geriatric depression impact cognitive status in an Indian urban elderly community Authors: Dongaonkar, Bhaktee; Singh, Arman Deep; Hurakadli, Swathi B.; Godbole, Ashwini Abstract: This study explored the cognitive status of community-dwelling Indian older adults. Our objective was to observe the association of age-related cognitive change with other physiological health parameters like, glycated hemoglobin (HbA1c), and vitamin B12 in older adults in India. Urban community dwelling, consenting older adults (55–85years, n = 123), with no clinical history of cognitive or neurological problems participated in the study. The participants underwent a detailed demographic documentation and cognitive assessment comprising of tests from different cognitive domains and blood-based assessment of glycated hemoglobin (HbA1c) and vitamin B12. As expected, performance in all cognitive domains declined with increasing age. HbA1c levels correlated inversely with processing speed and executive function. Vitamin B12 levels did not correlate with performance on any cognitive test. Interestingly, geriatric depression correlated inversely with visuospatial abilities. A stepwise multiple regression revealed that HbA1c and geriatric depression contributed to 28 % variance on Montreal Cognitive Assessment while age did not qualify as a significant contributor. Using Petersen’s criteria, Mild Cognitive Impairment (MCI) was observed in 17 % of participants. Participants classified as MCI had higher levels of HbA1c and geriatric depression, and lower performance in all cognitive domains compared to non-MCI participants. In conclusion, although cognitive performance declined with age, HbA1c and geriatric depression had a greater role in cognitive decline than age. With a high incidence of diabetes in India, this study highlights the prevalence of metabolism-linked changes in cognition, which are often ignored in community dwelling older adults in India. Thu, 01 May 2025 00:00:00 GMT http://tdudspace.texicon.in:8080/jspui/handle/123456789/719 2025-05-01T00:00:00Z http://tdudspace.texicon.in:8080/jspui/handle/123456789/712 Title: Sida cordifolia is efficacious in models of Huntington’s disease by reducing ER stress Authors: Simha, Prasanna K.; Godbole, Ashwini; Upadhyay, Sanjeev K. Abstract: Neurodegenerative disorders (NDs) are a major class of diseases where modern science has not succeeded in providing solutions to the desired levels. ER stress pathway is implicated in pathophysiology of several neurodegenerative disorders, especially those classified as proteinopathies. Several traditional medicines are used to treat neurodegeneration and Sida cordifolia (SC) is one of the common ingredients in formulations used for treating NDs and neuropathic pain. However, the mode of action is not clear. We studied the effectiveness of SC in Huntington’s Disease (HD) model using Caenorhabditis elegans and mammalian cells. Sat, 01 Mar 2025 00:00:00 GMT http://tdudspace.texicon.in:8080/jspui/handle/123456789/712 2025-03-01T00:00:00Z http://tdudspace.texicon.in:8080/jspui/handle/123456789/711 Title: Age-related cortical changes and cognitive performance in healthy adults Authors: Godbole, Ashwini; Khushu, Subash; Singh, Arman Deep; Kumar, Mukesh; B.H., Swathi; P, Bhargavi Abstract: Aging is a continuous process with cortical thinning as a common consequence. This study aimed to evaluate cortical thickness, volume and area differences associated with age in healthy population. Seventy-six healthy individuals were divided into three age groups: younger (25–40 years, n = 25), middleaged (41–55 years, n = 24), and older (56–80 years, n = 27). The elderly group exhibited significantly reduced cortical gray matter in frontal regions (left rostral middle frontal, bilateral lateral orbitofrontal, precentral gyri), temporal (middle temporal, right superior temporal, right inferior temporal), limbic regions (left insula, left posterior cingulate gyrus), occipital (right cuneus, lateral occipital, right lateral occipital), and parietal (precuneus and left postcentral gyri) compared to the younger group. Thu, 01 May 2025 00:00:00 GMT http://tdudspace.texicon.in:8080/jspui/handle/123456789/711 2025-05-01T00:00:00Z