Please use this identifier to cite or link to this item:
http://tdudspace.texicon.in:8080/jspui/handle/123456789/261| Title: | VDAC Properties are influenced by the source of its Purification |
| Authors: | Dubey, Ashvini K Godbole, Ashwini Srinivasan, Sujitha Mathew, M.K. |
| Keywords: | VDAC Mitochondria BLM Bacterial expression Purification. |
| Issue Date: | Aug-2014 |
| Publisher: | International Journal of Pharmacy and Pharmaceutical Sciences |
| Abstract: | The Voltage Dependent Anion-Selective Channel (VDAC), the most abundant protein of the outer mitochondrial membrane (OMM), forms the major conduit for metabolite transport across this membrane. It has also been shown to be involved in cell death signalling through interaction with other proteins like Hexokinase and by mediating release of apoptogenic proteins like cyt c from mitochondria. As in case of other channel proteins, functional characterization of purified reconstituted protein by using electrophysiological techniques can be used in development of VDAC targeted drugs. Here we report electrophysiological properties of VDACs (one of the target for cancerous cells) purified from different sources. |
| URI: | http://tdudspace.texicon.in:8080/jspui/handle/123456789/261 |
| Appears in Collections: | Faculty Publications |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJPPS VDAC source.pdf Restricted Access | 380.7 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.