An In-vitro Pilot Study to Explore Therapeutic Adjuvant Potential of Tinospora cordifolia with Methotrexate in Rheumatoid Arthritis Management

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease with increasing global burden. It is characterized by pain, swelling and inflammation at the site of bone joints. The inflammatory response plays a crucial role in RA pathogenesis. The present therapeutic approaches include extensive use of disease-modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX) with known adverse effects. Ayurveda, an Indian traditional medicine system may offer cues to manage RA. Tinospora cordifolia (TC/Guduchi) is an extensively prescribed botanical in Ayurveda practice for management of chronic inflammatory conditions. The present study explored the adjuvant potential of aqueous extract of TC (TCA) in combination with MTX using SW982 cells.