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http://tdudspace.texicon.in:8080/jspui/handle/123456789/542| Title: | Exploring the molecular correlates of Agni modulation by Lodhrasavam in adipose and liver tissue lipid metabolism |
| Authors: | Hegde, Swathi R |
| Keywords: | Ayurveda Biology Agni modulation Lodhrasavam lipid metabolism molecular correlation |
| Issue Date: | Jul-2024 |
| Publisher: | TDU |
| Abstract: | The Ayurvedic formulation Lodhrasavam, known to be helpful in the management of Sthoulya was tested for its effect on 3T3L1 cell model. Experiments were done to see the inhibitory action of Lodhrasavam on adipogenesis in 3T3L1 fibroblasts (i.e.,3T3L1 differentiation) and to see the lipolytic action of Lodhrasavam in mature 3T3L1 adipocytes. TAG assay, Oil O Red staining, and RT-PCR were done to estimate the effect. The results show that Lodhrasavam can significantly inhibit adipogenesis in 3T3L1 fibroblasts by inhibiting the expression levels of adipogenic genes like PPAR-ɣ, SREBP, FABP4 and CEBPA and can accelerate lipolysis in mature 3T3L1 adipocytes. |
| URI: | http://tdudspace.texicon.in:8080/jspui/handle/123456789/542 |
| Appears in Collections: | MSc Ayurveda Biology Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Swathi Thesis.pdf | 783.38 kB | Adobe PDF | View/Open |
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